Shengmin Sang Selected Research

shogaol

5/2014	Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.
2/2014	Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.
6/2013	Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice.
3/2013	Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.
1/2013	Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation.
4/2012	Metabolism of [6]-shogaol in mice and in cancer cells.
9/2010	6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.
3/2010	Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells.
11/2009	Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols.
5/2008	6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression.

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Shengmin Sang Research Topics

Disease

33	Neoplasms (Cancer) 04/2018 - 09/2005
21	Colonic Neoplasms (Colon Cancer) 11/2019 - 04/2003
11	Chronic Disease (Chronic Diseases) 01/2022 - 11/2005
8	Carcinogenesis 06/2013 - 12/2006
7	Heart Diseases (Heart Disease) 04/2018 - 08/2007
6	Obesity 07/2020 - 04/2011
5	Hyperglycemia 01/2019 - 03/2016
5	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 09/2005
5	Lung Neoplasms (Lung Cancer) 02/2014 - 03/2008
4	Inflammation (Inflammations) 11/2021 - 09/2010
4	Diabetes Complications 09/2017 - 04/2014
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 11/2005
3	Diabetes Mellitus 04/2008 - 12/2006
2	Body Weight (Weight, Body) 01/2019 - 05/2015
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 05/2015
2	Fatty Liver 01/2019 - 04/2011
2	Weight Gain 03/2017 - 04/2011
2	Skin Neoplasms (Skin Cancer) 01/2008 - 11/2007
1	Pain (Aches) 01/2022
1	Airway Remodeling 11/2021
1	Brain Edema (Cerebral Edema) 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Hemorrhage 01/2017
1	Cataract (Cataracts) 12/2016
1	Atherosclerotic Plaque (Atheroma) 10/2014
1	B-Cell Lymphoma (Lymphoma, B Cell) 05/2014

Drug/Important Bio-Agent (IBA)

16	TeaIBA 05/2019 - 09/2005
11	PolyphenolsIBA 09/2020 - 09/2005
10	shogaolIBA 05/2014 - 05/2008
9	Biological ProductsIBA 01/2020 - 12/2006
7	Pyruvaldehyde (Methylglyoxal)IBA 09/2020 - 12/2007
7	Advanced Glycation End ProductsIBA 07/2020 - 12/2006
7	Dietary Fiber FDA Link 11/2019 - 12/2006
6	gingerolIBA 01/2017 - 05/2008
5	PhytochemicalsIBA 01/2020 - 12/2006
4	CaspasesIBA 05/2014 - 05/2008
4	Arachidonic Acid (Vitamin F)IBA 01/2012 - 04/2003
3	Proteins (Proteins, Gene)FDA Link 02/2020 - 12/2007
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 05/2015
3	Insulin (Novolin)FDA Link 03/2017 - 04/2011
3	Cysteine (L-Cysteine)FDA Link 05/2014 - 06/2013
3	Glutathione (Reduced Glutathione)IBA 02/2014 - 03/2010
3	anthraceneIBA 06/2013 - 09/2010
3	Protein Kinases (Protein Kinase)IBA 06/2013 - 11/2005
3	CurcuminIBA 01/2012 - 09/2004
3	garcinolIBA 01/2012 - 09/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2010 - 04/2007
2	ginger extractIBA 01/2022 - 09/2015
2	GenisteinIBA 07/2020 - 01/2019
2	DNA (Deoxyribonucleic Acid)IBA 02/2020 - 11/2005
2	FlavonoidsIBA 01/2020 - 04/2014
2	AmmoniaIBA 01/2020 - 01/2019
2	AntioxidantsIBA 05/2019 - 11/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2018 - 09/2012
2	Blood Glucose (Blood Sugar)IBA 03/2017 - 04/2011
2	gallocatechol (epigallocatechin)IBA 03/2017 - 09/2005
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2017 - 08/2015
2	Cytochromes c (Cytochrome c)IBA 05/2014 - 02/2014
2	Acetylcysteine (Siran)FDA LinkGeneric 06/2013 - 03/2008
2	Glyoxal (Ethanedial)IBA 04/2008 - 12/2007
2	Caffeine (No Doz)FDA LinkGeneric 01/2008 - 02/2006
1	Mitochondrial DNA (mtDNA)IBA 01/2022
1	Acrolein (Aqualin)IBA 01/2022
1	Waste Products (Waste Product)IBA 01/2020
1	baicaleinIBA 01/2020
1	Butyrates (Butyrate)IBA 11/2019
1	compound 21IBA 11/2019
1	SolutionsIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 10/2018
1	avenanthramide-2CIBA 08/2018
1	GlucosidesIBA 08/2018
1	theaflavinIBA 04/2018
1	Dietary Advanced Glycation End ProductsIBA 02/2018
1	PhenolsIBA 09/2017
1	ProdrugsIBA 01/2017
1	CyclinsIBA 08/2015
1	Caspase 3 (Caspase-3)IBA 08/2015
1	Nonesterified Fatty Acids (NEFA)IBA 05/2015
1	salvinIBA 05/2015
1	Triglycerides (Triacylglycerol)IBA 05/2015
1	OxidesIBA 03/2015
1	SterolsIBA 03/2015
1	OxysterolsIBA 03/2015
1	CholesterolIBA 10/2014
1	Antineoplastic Agents (Antineoplastics)IBA 05/2014
1	X-Linked Inhibitor of Apoptosis ProteinIBA 05/2014
1	Caspase 9IBA 05/2014
1	QuercetinIBA 04/2014
1	PhloretinIBA 04/2014
1	Mitogen-Activated Protein Kinase 3IBA 06/2013
1	Cyclin BIBA 06/2013
1	galantide (M 15)IBA 05/2013
1	Sulfhydryl Compounds (Thiols)IBA 03/2013
1	SphingolipidsIBA 01/2013
1	8-(3-(4-hydroxy-3-methoxyphenyl) propanamido) octanoic acid ethyl esterIBA 01/2013
1	Hydroxyl RadicalIBA 09/2012

Therapy/Procedure

2	Chemoprevention 02/2014 - 01/2012
1	Ligation 01/2022
1	Therapeutics 11/2021
1	Fat-Restricted Diet (Diet, Fat Restricted) 12/2016